Utility of Axial Images in an Early Alzheimer Disease Diagnosis Support System (VSRAD)

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  • Goto Masami
    Department of Radiological Technology, University of Tokyo Hospital
  • Aoki Shigeki
    Department of Radiology, University of Tokyo Hospital
  • Abe Osamu
    Department of Radiology, University of Tokyo Hospital
  • Masumoto Tomohiko
    Department of Radiological Technology, University of Tokyo Hospital
  • Watanabe Yasushi
    Department of Radiological Technology, University of Tokyo Hospital
  • Satake Yoshiroh
    Department of Radiological Technology, University of Tokyo Hospital
  • Nishida Katsuji
    Department of Radiological Technology, University of Tokyo Hospital
  • Ino Kenji
    Department of Radiological Technology, University of Tokyo Hospital
  • Yano Keiichi
    Department of Radiological Technology, University of Tokyo Hospital
  • Iida Kyohhito
    Department of Radiological Technology, University of Tokyo Hospital
  • Mima Kazuo
    Department of Radiological Technology, University of Tokyo Hospital
  • Ohtomo Kuni
    Department of Radiology, University of Tokyo Hospital

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Other Title
  • 早期アルツハイマー型痴呆診断支援システム（ＶＳＲＡＤ）における水平断画像の有用性
  • 早期アルツハイマー型痴呆診断支援システム(VSRAD)における水平断面像の有用性
  • ソウキ アルツハイマーガタ チホウ シンダン シエン システム VSRAD ニ オケル スイヘイ ダンメンゾウ ノ ユウヨウセイ

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Abstract

In recent years, voxel-based morphometry (VBM) has become a popular tool for the early diagnosis of Alzheimer disease. The Voxel-Based Specific Regional Analysis System for Alzheimer's Disease (VSRAD), a VBM system that uses MRI, has been reported to be clinically useful. The able-bodied person database (DB) of VSRAD, which employs sagittal plane imaging, is not suitable for analysis by axial plane imaging. However, axial plane imaging is useful for avoiding motion artifacts from the eyeball. Therefore, we created an able-bodied person DB by axial plane imaging and examined its utility. We also analyzed groups of able-bodied persons and persons with dementia by axial plane imaging and reviewed the validity. After using the DB of axial plane imaging, the Z-score of the intrahippocampal region improved by 8 in 13 instances. In all brains, the Z-score improved by 13 in all instances.

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