肥満児の血中脂質レベルとβ-リポ蛋白

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  • Relationship of Plasma Lipids and β-lipoproteins to Obesity in Children
  • ヒマンジ ノ ケッチュウ シシツ レベル ト ベータ-リポ タンパク エイブン

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Plasma lipids and β-lipoproteins were measured in obese and non-obese boys of ages of 12 to 14, who were born in Hokkaido and living in Asahikawa, Hokkaido, one of the coldest areas of Japan.<br>Triglycerides (TG), cholesterol ester and β-lipoproteins were significantly higher in the obese group, while there were no statistically significant differences in total cholesterol and free fatty acids between the obese and non-obese subjects.<br>Adiposity expressed in terms of skinfold thickness (triceps+subscapular/2) and estimated fat percentage was positively correlated with β-lipoproteins and less with cholesterol ester. No significant association was found between adiposity and TG or total cholesterol.<br>β-lipoproteins also showed a highly positive correlation with TG, total cholesterol and cholesterol ester.<br>These results imply that blood β-lipoproteins could be a feasible and useful tool for demonstrating abnormalities in lipid metabolism in obesity of children.<br>The clinical association of obesity with the occurrence of cardiovascular disorders has been extensively explored. According to many studies of 10 to 20 year follow-up of obese children, over 75 per cent of obese children maintain or increase their obesity in adult life. Thereupon, it is important to prevent and treat gross obesity in childhood.<br>A relationship between blood lipids and adiposity has been reported both in adults and children by several investigators, indicating abnormal pictures in lipid metabolism of obese subjects. Obese children have been found to show elevated levels in blood free fatty acids, glycerol, triglycerides, cholesterol and total lipids. It is also widely accepted that lipid metabolism is significantly involved in the metabolic responses of homeotherms to low environmental temperature. Therefore it seems to be necessary to study obese children living in cold areas from the view point of lipid metabolism in order to understand their substantial states. Previously we reported that obese children living in Asahikawa, one of the coldest areas of Japan, were characterized by an elevated level of plasma triglycerides, while in disaccord with other reports, no significant difference in plasma free fatty acids level was found between normal and obese children. This might be peculiar to obese children living in cold areas, since free fatty acids metabolism could be modified in the process of cold acclimatization.<br>The present study concerns cholesterol and β-lipoproteins, both of which have been claimed to be responsible for the development of atherosclerosis, in obese children in Asahikawa.

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