ウサギの尿中グルクロン酸排泄に対する二硫化炭素,ベンゾール及び鉛化合物の影響

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  • Glucuronic acid excretion in urine of rabbits by exposure to carbon disulfide, benzol, and lead
  • ウサギ ノ ニョウ チュウ グルクロンサン ハイセツ ニ タイスル 2リュウカ タンソ , ベンゾール オヨビ ナマリ カゴウブツ ノ エイキョウ

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The importance of glucuronic acid in the detoxication mechanisms has been widely recognized. The present experiments were made with rabbits which were exposed to carbon disulfide, benzol and lead, which are usually used in the today's Japanese industry. An exposing chamber for carbon disulfide was designed so as to regulate its concentration as high as 500ppm. The animals were divided into three groups and each group was exposed twice with a single exposure duration of 3, 6.5 and 12 hours. In order to induce lead and benzol absorption, the animals were injected subcutaneously twice with lead acetate solution, corresponding to 10mg/kg for lead and once with 176mg/kg of benzol respectively.<br>Analyses of urinary glucuronic acid and ether glucronide were carried out by the naphtoresorcin picrate method. The concentration of urinary glucuronic acid was corrected by the concentration of urinary creatinine. Thus the concentration of glucuronic acid was expressed as G/C ratio in urine. Principal results obtained were as follows.<br>1) After inhalation of carbon disulfide, G/C ratio in urine began to decrease rapidly and returned slowly to the normal range in about a week after cessation on inhalation.<br>2) The plasma cholesterol level and A/G ratio as well as GPT of the serum were little varied even after 12 hour inhalation of carbon disulfide. From these facts, it would be suggested that the decreased excretion of urinary glucuronic acid is not due to the impairement of the liver by carbon disulfide, but may be due to other, perhaps, neurological or endocrinological mechanisms.<br>3) The increase of G/C ratio in urine was found in the case of administration of benzol.<br>4) No change concerning the excretion of urinary glucuronic acid was resulted by administration of lead.

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