20-メチル・コラントレンの骨髄内注入による実験的腫瘍形成について

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  • 大林 功
    東京医科歯科大学医学部衞生学教室

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タイトル別名
  • Studies on the Experimental Tumor Formation by Intramedullary Injection of 20 Methyl-Cholanthrene
  • 20-メチル コラントレン ノ コツズイ ナイ チュウニュウ ニ ヨル ジッケンテキ シュヨウ ケイセイ ニ ツイテ

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The 20-methyl-cholanthrene emulsions were injected to the bone marrow of femur of rats suspended in propylenglycol, rape-oil, croton-oil and saline and the tumor formation was persued during fourty-five weeks.<br>About ninety subjects were used for the experiments in four groups, such as the propyleneglycol's (P), the rape-oil's (R), the croton-oil's (C) and the saline's (A). The results obtained were followings.<br>1) The neoplastic findings in four groups were as follows. For A group, no neoplastic findings were appeared in 10 subjects, for P group, neoplastic findings were appeared 10 cases in 45 subjects, for R group, 8 cases in 22 subjects, and for C group, 9 cases in 15 subjects.<br>2) To classify the locations of tumors in the diaphysis region and in the epiphysis one, 21 cases were belonged to the former and 6 cases to the latter.<br>3) To classify the patterns of tumors, 18 cases were belonged to the polymorph-cell sarcoma, 7 cases to the fibrosarcoma and 2 cases to the spindlecell sarcoma.<br>4) For the rats with tumor formation, various marked changes were observed roentgenologically.<br>5) No metastasis to the other organs was found.<br>6) The transplantation of the tumor to the other subjects were succeeded in 3 cases.

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