Effect of polychlorinated biphenyls (PCB) on metabolism of thyroid hormone inWistar rats.

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  • Yamane Teruko
    Division of Clinical Research, National Institute of Radiological Sciences
  • Fukuda Nobuo
    Division of Clinical Research, National Institute of Radiological Sciences
  • Inaba Jiro
    Division of Environmental Health, National Institute of Radiological Sciences
  • Nishimura Yoshikazu
    Division of Environmental Health, National Institute of Radiological Sciences

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Other Title
  • PCBのラット甲状腺ホルモンの代謝に及ぼす影響
  • PCBのラット甲状腺ホルモンの代謝に及ぼす影響〔英文〕
  • PCB ノ ラット コウジョウセン ホルモン ノ タイシャ ニ オヨボス エイ

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In an attempt to study the effect of polychlorinated biphenyls on iodine metabolism, Kanechlor KC-400 (a mixture of PCB) was administered to rats.<br>At 3, 10, 20 and 30 days after a single oral administration of KC-400, the following studies were performed; 1) weighing of liver and thyroid, 2) Kinetics of whole-body 131I-thyroxine, 3) biliary excretion of 131I-thyroxine, 4) analysis of the radioactive components in the bile.<br>A single administration of 200mg dose of KC-400 drastically affected the iodine metabolism of rats as follows; the weights of liver and thyroid were increased at least for 30 days, elimination of thyroxine from the whole body was accelerated, the biliary excretion of thyroxine was enhanced at least for 20 days, and throxine gluculonide in bile increased for two hours after injection of 131I-thyroxine.

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