内視鏡下測定による諸種条件下の胃粘膜potendal difference (PD) 変化とその臨床的意義

DOI Web Site Web Site

書誌事項

タイトル別名
  • The change of the gastric mucosal potential difference (GMPD) on various conditions, measured under endoscopic direct vision and its clinical significance
  • ナイシキョウカ ソクテイ ニヨル ショシュ ジョウケンカ ノ イ ネンマク p

この論文をさがす

抄録

In animal studies the gastric mucosal potential difference (GMPD) is considered to be a useful indicator for dynamic change in the gastric mucosal barrier;i.e.GMPD decreases when gastric mucosa is damaged with H + back diffusion. Under endoscopic direct vision, the change of GMPD on various conditions was measured in human, and the following results were obtained.<BR>GMPD measurement: A teflon catheter filled with 3 M-KCl in 3% agarwas used as an electrolyte bridge which passed through the forceps channel of the operating endoscope.The probe electrode (Ag-Ag CL) was placed on the mucosal surface and the reference electrode was attached to the thigh skin.<BR>pH measurement The glass electrode was placed on the mucosal, surface and the reference electrode was set on oral mucosa.<BR>Histological examination: In order to evaluate the grade of mucosal damage in relation to GMPD change, mucosal specimens obtained by aimed biopsy were examined under a light microscope.<BR>Results:(1) Spray of antacids such as Na HCO3 or maalox onto the mucosal surface caused a remarkable rise of surface pH, but GMPD did not change.(2) Intravenousinjection of cimetidine and atropine sulfate: GMPD increased remarkably after cimetidine, but not influenced by atropine sulfate, while surface pH was not changed by both drugs.(3) Spray of 0.1 N HCl onto the mucosal surface caused a fall of surface pH and a distinguishable increase in GMPD. Intramuscular injection of tetragastrin or betazole hydrochloride resulted in a fall of (4su) rface pH and a remarkable decrease in GMPD.(5) Spray of acetylsalicylic acid, ethanol or urea onto the mucosal surface caused a remarkable decrease in GMPD and at thesame time, damage of the surface epithelial cell was observed.(6) Taurocholic acid, glycocholic acid or lysolecithin caused an obvious decrease in GMPD and damage of the surface epithelial cell was also observed. Pretreatment with maalox protected the gastric mucosa to some extent from a redu (c7t) ion of GMPD induced by glycocholic acid.(8) GMPD was generally less, while the difference of GMPD between the greater and lesser curvature was more in gastric ulcer than in duodenal ulcer.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ