The diagnosis of hepatocellular carcinoma determined by pattern of AFP bands separated by Con A affinity electrophoresis.
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- SAITO Satoshi
- Department of Gastroenterology, Toranomon Hospital
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- IKEDA Kenji
- Department of Gastroenterology, Toranomon Hospital
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- KOIDA Isao
- Department of Gastroenterology, Toranomon Hospital
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- TSUBOTA Akihito
- Department of Gastroenterology, Toranomon Hospital
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- ARASE Yasuji
- Department of Gastroenterology, Toranomon Hospital
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- CHAYAMA Kazuaki
- Department of Gastroenterology, Toranomon Hospital
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- KANDA Masumi
- The Liver Research Laboratory of Toranomon Hospital
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- KOBAYASHI Mariko
- The Liver Research Laboratory of Toranomon Hospital
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- KUMADA Hiromitsu
- Department of Gastroenterology, Toranomon Hospital
Bibliographic Information
- Other Title
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- Ｃｏｎ Ａ結合性ＡＦＰ亜分画分析による肝細胞癌の診断
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Abstract
We analyzed the Con A affinity of serum AFP in patients with a serum AFP concentration greater than 50ng/ml by antibody affinity electrophoresis and Western blotting to distinguish hepatocellular carcinoma (HCC) from benign chronic liver diseases (CLD). Of 164 patients with HCC, 48 (29.3%) had a single band, while 116 (70.7%) had multiple bands. All but three of 65 patients with cirrhosis had a single band. All but one of 32 patients with chronic hepatitis had a single band. We concluded that multiple AFP bands are diagnosis of HCC. This method is a useful assay for distinguishing HCC from CLD.
Journal
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- Nippon Shokakibyo Gakkai Zasshi
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Nippon Shokakibyo Gakkai Zasshi 91 (8), 1301-1308, 1994
The Japanese Society of Gastroenterology