Reestimation of aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio based on JSCC consensus method. Changes of criteria for a differential diagnosis of hepatic disorders following the alteration from Karmen method to JSCC method.

DOI PubMed 4 Citations
  • KOTANI Kazuo
    Department of Laboratory Medicine, Hamamatsu University School of Medicine
  • MAEKAWA Masato
    Department of Laboratory Medicine, Hamamatsu University School of Medicine
  • KANNO Takashi
    Department of Laboratory Medicine, Hamamatsu University School of Medicine

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  • 日本臨床化学会（ＪＳＣＣ）常用基準法に基づいたａｓｐａｒｔａｔｅ　ａｍｉｎｏｔｒａｎｓｆｅｒａｓｅ（ＡＳＴ）／ａｌａｎｉｎｅ　ａｍｉｎｏｔｒａｎｓｆｅｒａｓｅ（ＡＬＴ）比の再設定　Ｋａｒｍｅｎ法からＪＳＣＣ常用基準法への変更に伴う肝疾患評価基準の変化
  • Changes of criteria for a differential diagnosis of hepatic disorders following the alteration from Karmen method to JSCC method
  • Karmen法からJSCC常用基準法への変更に伴う肝疾患評価基準の変化

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We estimated clinical criteria of aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio that is measured by the consensus method of JSCC (Japan Society of Clinical Chemistry) for serum AST and ALT. The JSCC consensus method is closely correlated with both IFCC (International Federation of Clinical Chemistry) recommended method without pyridoxal phosphate and Karmen method recommended by the expert panel of liver function tests in Japanese Society of Gastroenterology. The slopes of the regression line is estimated to be 1.00 and 0.87 respectively.<BR>We propose that the decision making value of AST/ALT ratio to differentiate several types of liver diseases should be set to 0.87 measured by JSCC consensus method, instead of 1.0 measured by Karmen method.

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