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- YAMASHITA Sachiko
- Division of Gastroenterology, Department of Medicine, Kawasaki Medical School
Bibliographic Information
- Other Title
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- 肝・胆道疾患における高比重リポたんぱくに関する研究
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Description
Serum levels of cholesterol of high density lipoprotein (HDL-Ch) were examind in 215 cases of liver diseases using Heparin-Ca method. Mean value of HDL-Ch was 61.89±10.74mg/dl in normal controls, while those of liver diseases were significantly reduced (p<0.001).<br>Serum HDL-Ch levels correlated well with alkaline phosphatase, choline esterase, albumin, LCAT activity, and maximum osmotic resistance of erythrocytes. Thus the measurement of serum HDL-Ch could be said to be useful for the evaluation of the severity of liver damages.<br>The lipoprotein fractions isolated by sequential ultracentrifugation were examind by both agarose-gel electrophoresis and electron microscopy and the absence of a-lipoprotein bands and marked decrease of HDL particles were confirmed. These observations indcate that severe hepatobiliary injury is associated with profound alteration in lipoprotein composition and metabolism.
Journal
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- Nippon Shokakibyo Gakkai Zasshi
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Nippon Shokakibyo Gakkai Zasshi 79 (2), 249-258, 1982
The Japanese Society of Gastroenterology