SALIVARY AND PANCREATIC AMYLASE CLEARANCE TO CREATININE CLEARANCE RATIOS IN PATIENTS WITH CHRONIC RENAL FAILURE
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- YAMAMOTO Makoto
- The Second Department of Internal Medicine, School of Medicine, Kanazawa University
Bibliographic Information
- Other Title
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- 慢性腎不全患者におけるアミラーゼ•クレアチニン• クリアランス比(CAm/CCr)について
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Description
Salivary and pancreatic amylase clearance to creatinine clearance ratios in 19 patients with chronic renal failure, were compared with those obtained for normal control subjects.<br>Hyperamylasemia was frequently observed. Both serum salivary and pancreatic amylase levels were elevated in most patients. The highest serum amylase activity was 774IU/L, less than 2 times value of normal upper limit.<br>Amylase clearance (0.42±0.24 ml/min) was reduced markedly in chronic renal failure. Salivary and pancreatic amylase clearances changed in parallel to that of total amylase, but these clearances were by different ratios reduced to about one fifth (0.30±0.18ml/min, salivary) and one seventh (0.53±0.32 ml/min, pancreatic) of those in controls. Normal control values were 2.45±0.73ml/min (total), 1.45±0.68ml/min (salivary) and 3.69±1.01ml/min (pancreatic), respectively.<br>Amylase clearance to creatinine clearance ratio of the patients with chronic renal failure (4.47±2.84%) was significantly higher (p<0.05) than that in controls (2.60±0.59%). The clearance ratio for salivary amylase (3.48±2.87%) was also significantly higher (p<0.01) than in controls. But this ratio for pancreatic amylase (5.33±2.81 %) was not significantly higher. Corresponding control values were 1.52±0.46% (salivary) and 3.96±0.97% (pancreatic).<br>Of the nine patients who showed raised clearance ratios, eight had less than 10ml/min of creatinine clearance value and one had 10.2ml/min. Amylase clearance to creatinine clearance ratio in chronic renal failure was inversely related to creatinine clearance (r=-0.5587, p<0.05). All patients studied did not have clinical evidence of pancreatic disease, indicating that in the presence of severe chronic renal failure a high clearance ratio need not be indicative of acute pancreatitis.<br>These results are compatible with the suggestion that in severe renal failure the loss of nephrons results in decreased fractional reabsorption of amylase in the tubules.
Journal
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- Nippon Shokakibyo Gakkai Zasshi
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Nippon Shokakibyo Gakkai Zasshi 77 (2), 246-255, 1980
The Japanese Society of Gastroenterology
