Therapy-related myelodysplastic syndrome as a late adverse event of definitive chemoradiotherapy for esophageal and oropharyngeal cancer
-
- KAMIHARA Yusuke
- Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
-
- SATO Yasushi
- Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
-
- TAKADA Kohichi
- Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
-
- OKAGAWA Yutaka
- Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
-
- IYAMA Satoshi
- Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
-
- SATO Tsutomu
- Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
-
- MIYANISHI Koji
- Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
-
- TAKIMOTO Rishu
- Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
-
- KOBUNE Masayoshi
- Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
-
- KATO Junji
- Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
Bibliographic Information
- Other Title
-
- 食道癌および中咽頭癌に対する根治的化学放射線併用療法の晩期有害事象と考えられたtherapy-related myelodysplastic syndromeの1例
Search this article
Abstract
The risks of myelodysplastic syndrome (MDS) and acute leukemia are increased in patients previously treated for other malignancies. Therapy-related MDS (t-MDS) occurs after exposure to certain cytotoxic agents or radiation used for cancer treatment. We report a case of t-MDS following curative chemoradiotherapy (CRT) for esophageal and oropharyngeal cancer. An 80-year-old male diagnosed with double cancers of the esophagus and oropharynx underwent definitive CRT and achieved a complete response. Six years later, he became anemic, and bone marrow examination showed 3.4% blast cells with fine chromatin structures and basophilic cytoplasm. Cytogenetic analysis indicated a complex karyotype that included chromosome 5 and 7 abnormalities. These findings were consistent with t-MDS. Subsequently, he developed acute myeloid leukemia and died 8 months later. This case indicates that long-term surveillance is needed to closely monitor the risk of t-MDS in patients treated with CRT.
Journal
-
- Nippon Shokakibyo Gakkai Zasshi
-
Nippon Shokakibyo Gakkai Zasshi 112 (9), 1664-1673, 2015
The Japanese Society of Gastroenterology