Some Observations on the Fine Structure of the Tubuli Seminiferi Contorti of Hypophysectomized Rats

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  • 下垂体摘出ラットの曲精細管の微細構造
  • カスイタイ テキシュツ ラット ノ キョク セイサイカン ノ ビサイ コウゾウ エイブン

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Abstract

Using the light and electron microscope, the authors studied on the alteration of the seminiferous tubule of the rat testes 5, 10, 20, and 30 days after hypophysectomy.<br>In all the experimental animals, no normal matured sperms were observed by light microscopy.<br>The spermatogonia show no marked changes in fine structure even 30 days after the operation.<br>The characteristic changes are seen in the spermiogenesis in the hypophysectomized animals.<br>All the spermatids seem to degenerate at the stage of the acrosomal formation. The degenerative process is as follows; (1) elongation and dilatation of the smooth endoplasmic reticulum, (2) alteration, destruction and disappearance of the mitochondria and of the Golgi apparatus, (3) decrease in number of polyribosomes, (4) deposit of the heterogeneously dense substances in the cytoplasmic matrix, and (5) alteration of the nucleus.<br>The degenerative spermatids are considered to be phagocytized in the Sertoli cell. The dense bodies containing myeline figures and heterogeneously dense materials, and lipid droplets are markedly increased in number and size in the Sertoli cells of all the experimental animals. The acid phosphatase reaction is strongly positive in the dense body, but not in the lipid droplet.<br>In the spermatid of the early degenerative process, the reaction product of the acid phosphatase is also recognized in the Golgi zone.

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