Antihypertensive Effect of Honey-Based Beverage Containing Fermented Rice Bran in Spontaneously Hypertensive Rats

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  • 自然発症高血圧ラットにおける米糠発酵エキス配合飲料の血圧上昇抑制作用
  • シゼン ハッショウ コウケツアツ ラット ニ オケル コメヌカ ハッコウ エキス ハイゴウ インリョウ ノ ケツアツ ジョウショウ ヨクセイ サヨウ

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The effect of oral administration of a honey-based beverage containing γ-aminobutyric acid (GABA)-fermented rice bran on blood pressure was investigated in spontaneously hypertensive rats. The control beverage or beverage containing GABA (10.1mg/kg per day) was administered to 12-week-old male rats for 8 weeks. After 3 weeks administration, blood pressure in rats administered the GABA beverage was lower than that in the control group, while it was significantly decreased on week 7 (218 vs. 234mmHg, P<0.05). In conclusion, oral chronic administration of the GABA beverage to spontaneously hypertensive rats appears to be beneficial and may improve hypertension.

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