The Effect of a Peptide (Ile-Val-Tyr) Derived from Royal Jelly Treated with Protease on Blood Pressure of Spontaneously Hypertensive Rat

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  • 蛋白質分解酵素処理ローヤルゼリー由来ペプチド (Ile-Val-Tyr) の血圧降下作用
  • タンパクシツ ブンカイ コウソ ショリ ローヤルゼリー ユライ ペプチド Ile Val Tyr ノ ケツアツ コウカ サヨウ

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We examined an antihypertensive effect of a peptide (Ile-Val-Tyr, IVY) derived from royal jelly treated with protease, on spontaneously hypertensive rats (SHR). In single oral administration of IVY at doses of 1.0 and 10 mg/kg body weight, systolic blood pressure (SBP) were significantly decreased against the control at doses of 1.0 and 10 mg/kg body weight. SBP was reduced at 1 h after administration of IVY and the effect was continued for 8 h. In repeated oral administration of IVY at doses of 1.0 and 10 mg/kg/day for 28 days, the SBP of the SHR was significantly decreased against the control at 7day and the effect continued for 28 days. During this experiment, heart rate (HR) and body weight were not changed. The repeated administration of IVY did not affect the SBP and HR of normotensive rat (Wistar Kyoto rat) for 28 days. These results suggest that the antihypertensive effect of IVY is concerned with antihypertensive effect of royal jelly treated with protease.

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