γ‐アミノ酪酸(GABA)含有酵母エキスの脳卒中易発症性高血圧自然発症ラットに対する血圧上昇抑制作用

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  • Effect of GABA Containing Yeast Extract on Blood Pressure to SHRSP.
  • ガンマ アミノラクサン GABA ガンユウ コウボ エキス ノ ノウソッチュウイハッショウセイ コウケツアツ シゼン ハッショウ ラット ニ タイスル ケツアツ ジョウショウ ヨクセイ サヨウ

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The effect of γ-aminobutyric acid (GABA) in yeast extract on blood pressure of stroke-prone spontaneously hypertensive rat (SHRSP) were examined. Two groups of SHRSP were fed 20mg GABA/kg and 40mg GABA/kg respectively, for a month. The systolic blood pressure (SBP) of the two groups were significantly lower, 11mmHg (20mg/kg) and 26mmHg (40mg/kg), compared with the control group after a month. The diastolic blood pressure (DBP) of the two group were also significantly lower, 12mmHg (20mg/kg) and 17mmHg (40mg/kg). Heart rate of the two groups also dropped. Reduction in plasma adrenaline level was observed in 40mg GABA/kg group. These results suggested that GABA in yeast extract had a hypotensive effect.

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