Antihyperglycemic and Antioxidant Effects of Flesh and Peel from Pomace of Viburnum dilatatum on Normal and Diabetic Mice

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  • Iwai Kunihisa
    Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare Graduate School of Health Sciences, Aomori University of Health and Welfare
  • Onodera Akio
    Onodera Brewhouse Co.
  • Iwai Kayo
    Graduate School of Health Sciences, Aomori University of Health and Welfare
  • Morinaga Yae
    Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare
  • Matsue Hajime
    Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare Graduate School of Health Sciences, Aomori University of Health and Welfare

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  • ガマズミ果実搾汁残渣から分離した果肉皮粉末の血糖上昇抑制および抗酸化作用
  • ガマズミ カジツサクジュウ ザンサ カラ ブンリ シタ カニク ヒ フンマツ ノ ケットウ ジョウショウ ヨクセイ オヨビ コウサンカ サヨウ

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Abstract

The antihyperglycemic and antioxidant effects of flesh and peel powder, which were isolated from the pomace of Viburnum dilatatum fruit (VPFPP), were investigated in normal and diabetic mice in order to find methods of utilizing this previously unused resource and to reduce waste. There were no negative effects on the growth and plasma biochemistries of mice that were fed a 1% VPFPP-containing diet for four weeks. Normal mice fed VPFPP did not show any elevation of non-fasting plasma glucose level. However, when VPFPP was fed to KK-Ay mice, a type 2 diabetic model mouse, the mice showed a dose-dependent suppression of increasing plasma glucose and insulin levels. When sucrose was administered orally into the fasted mice, a dose-dependent suppression of elevating plasma glucose concentration was also found in the KK-Ay mice that were fed VPFPP diets. It was considered that these inhibitory effects were induced by the α-glucosidase inhibitory activity of polyphenols and the large amount of dietary fiber contained in VPFPP. Moreover, increase of plasma lipid peroxidation was suppressed by VPFPP ingestion in KK-Ay mice. These results suggested that the flesh and peel from the pomace of V. dilatatum might be a new functional material with antioxidant and antihyperglycemic potencies.

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