Functions of Chitosan .ALPHA.-Lipoic Acid Salt in the Gut

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  • キトサン‐α‐リポ酸塩の消化管内機能
  • キトサン-α-リポ酸塩の消化管内機能
  • キトサン アルファ リポ サンエン ノ ショウカ カンナイ キノウ

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Abstract

We prepared CS-ALA, the α-lipoic acid (ALA) salt of chitosan, and investigated the adsorption of primary or secondary bile acid and the release of ALA in vitro. Calcium-induced alginate gel beads (Alg-Ca) containing CS-ALA were also prepared, and the usability of these beads as a vehicle for oral administration was investigated. When CS-ALA was soaked in a taurocholate solution, it released ALA and simultaneously adsorbed bile acid. The adsorbed amount of taurodeoxycholate, a secondary bile acid, was higher than that of taurocholate. These two functions were recognized in Alg-Ca containing CS-ALA irrespective of water content of the gel matrix. As all these elements can be ingested as food, Alg-Ca containing CS-ALA could serve as a useful dietary agent for the prevention of colon cancer.

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