Hypoglycemic Effect of Glechoma hederacea Extract on Blood Glucose Level in Rats

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  • Ishihara Shinji
    Yaegaki Technology Development Laboratories, Yaegaki Bio-industry, Inc.
  • Kawata Ayumi
    Yaegaki Technology Development Laboratories, Yaegaki Bio-industry, Inc.
  • Inoue Miho
    Yaegaki Technology Development Laboratories, Yaegaki Bio-industry, Inc.
  • Watanabe Toshiro
    Yaegaki Technology Development Laboratories, Yaegaki Bio-industry, Inc.
  • Tsuji Keisuke
    School of Human Science and Environment, University of Hyogo

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  • ラットにおけるカキドオシ抽出物の血糖値上昇抑制作用
  • ラット ニ オケル カキドオシ チュウシュツブツ ノ ケットウチ ジョウショウ ヨクセイ サヨウ

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Abstract

A hot water extract was prepared from Glechoma hederacea subsp. grandis leaves and stem, and its anti-diabetic effect was examined in vivo. Single dose oral administration of the Glechoma extract significantly lowered blood glucose 30-60min after sucrose loading in Wistar rats (p<0.01) and 60-90min after sucrose loading in streptozotocin diabetic rats (p<0.05). Single dose oral administration of the eluated fraction from solid-phase extraction significantly lowered blood glucose 30-90min after sucrose loading in Wistar rats (p<0.05). These results suggest that the Glechoma extract may prevent increases in postprandial blood glucose level.

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