Hypotensive Effect of Anthocyanin-rich Extract from Purple-fleshed Sweet Potato Cultivar "Ayamurasaki" in Spontaneously Hypertensive Rats

DOI Web Site 8 Citations 11 References
  • Kobayashi Mio
    Research Fellow of Cooperative System for Supporting Priority Research
  • Oki Tomoyuki
    National Agricultural Research Center for the Kyushu Okinawa Region, National Agriculture and Bio-oriented Research Organization
  • Masuda Mami
    Research Fellow of Cooperative System for Supporting Priority Research
  • Nagai Saki
    Research Fellow of Cooperative System for Supporting Priority Research
  • Fukui Keiichi
    Miyazaki JA Food Research & Development Inc.
  • Matsugano Kazusato
    Miyazaki JA Food Research & Development Inc.
  • Suda Ikuo
    National Agricultural Research Center for the Kyushu Okinawa Region, National Agriculture and Bio-oriented Research Organization

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Other Title
  • 紫サツマイモ「アヤムラサキ」から調製したアントシアニン含有物の高血圧自然発症ラットに対する血圧降下作用
  • ムラサキ サツマイモ アヤムラサキ カラ チョウセイ シタ アントシアニン ガンユウブツ ノ コウケツアツ シゼン ハッショウ ラット ニ タイスル ケツアツ コウカ サヨウ

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Abstract

We prepared anthocyanin-rich extract from purple-fleshed sweet potato (Ipomoea batatas (L.) Lam.) cultivar “Ayamurasaki” (PSP-ANT) and examined hypotensive effect of PSP-ANT in spontaneously hypertensive rats (SHR). After a single ingestion (400 mg/kg p.o.) of PSP-ANT, a significant decrease of systolic blood pressure (p<0.05) was observed at 2 hours postadministration and the decrease was prolonged until 8 hours postadministration in SHR. The antihypertensive effect was also observed in a long-term ingestion (0.1 and 0.2% diet for 8 weeks) of PSP-ANT in SHR. After stopping the feed of PSP-ANT, the systolic blood pressure was almost the same as that of SHR fed control diet.

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