Occurrence of a tetrodotoxin-associated substance in a gastropod, "hanamushirogai" Zeuxis siquijorensis.

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  • NARITA Hiroko
    Shizuoka Prefectural Institute of Public Health and Environmental Science
  • NOGUCHI Tamao
    Laboratory of Marine Biochemistry, Faculty of Agriculture, The University of Tokyo
  • MARUYAMA Junichi
    Laboratory of Marine Biochemistry, Faculty of Agriculture, The University of Tokyo
  • NARA Masato
    Shizuoka Prefectural Institute of Public Health and Environmental Science
  • HASHIMOTO Kanehisa
    Laboratory of Marine Biochemistry, Faculty of Agriculture, The University of Tokyo

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Other Title
  • 巻貝ハナムシロガイ<i>Zeuxis siquijorensis</i>からのテトロドトキシン関連物質の分離
  • 巻貝ハナムシロガイZeuxis siquijorensisからのテトロドトキシン関連物質の分離〔英文〕
  • マキガイ ハナムシロガイZeuxis siquijorensis カラ ノ テ

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Abstract

A paralytic toxin was detected in a gastropod, “hanamushirogai” Zeuxis siquijorensis collected from the coast of Shimizu. The toxin was partially purified, essentially by a purification method of tetrodotoxin (TTX), and compared with an authentic specimen of TTX.<br> “Hanamushirogai” toxin clearly differed from TTX in both thin-layer chromatographic and electrophoretic behaviors. Their dose-death time curves in mice did not superimpose on each other. However, it was demonstrated by GC-MS that “hanamushirogai” toxin gives rise to C9-base (2-amino-6-hydroxymethy1-8-hydroxyquinazoline) when hydrolyzed with alkali.<br> It was concluded from these results that the toxin is a TTX-associated substance which contains the quinazoline skeleton (C9-base) as does TTX.

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