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- Watanabe Takaoki
- Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
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- Hasegawa Go
- Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences
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- Yamamoto Takashi
- Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences
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- Hatakeyama Katsuyoshi
- Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
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- Suematsu Makoto
- Department of Biochemistry, School of Medicine, Keio University
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- Naito Makoto
- Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences
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説明
Heme oxygenase (HO), the heme-degrading enzyme, plays an important role in heme catabolism. Among three isozymes, HO-1 is an inducible form expressed mainly in macrophages. In rat ontogeny, HO-1 immunoreactivity was detected in mononuclear cells in the yolk sac at 10 days of gestation. HO-1-expressing cells were then detected in the fetal liver and their numbers increased during the gestational period. The numbers of HO-1-positive cells and HO-1 mRNA levels in the liver peaked at 18 days of gestation. Most of the macrophages expressed both HO-1 and a macrophage scavenger receptor. Macrophages in the fetal liver showed marked hemophagocytosis. Macrophages in the lung, spleen, bone marrow, and other tissues also expressed HO-1. HO-1 immunoreactivity was also observed in syncytial cells of the chorionic villi, the endodermal layer of the yolk sac, and renal tubules of the fetus. Intestinal mucosal epithelial cells expressed HO-1 after birth. These findings imply that HO-1 is crucial for macrophages in heme catabolism from an early stage of ontogeny. HO-1 expression in non-macrophagic cells may be required for other purposes such as protection from oxidative stress and various stimuli.
収録刊行物
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- Archives of Histology and Cytology
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Archives of Histology and Cytology 66 (2), 155-162, 2003
国際組織細胞学会
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詳細情報 詳細情報について
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- CRID
- 1390001206412947456
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- NII論文ID
- 130004462611
- 10011992787
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- NII書誌ID
- AA1068990X
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- ISSN
- 13491717
- 09149465
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- PubMed
- 12846555
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 使用不可