Studies on the Mechanism of Antibiotic Action of Vitamin K-III

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Other Title
  • ビタミンKの抗菌作用機構-III
  • ビタミン K ノ コウキン サヨウ キコウ 3
  • Effect of Vitamin K on the Enzymatic Activities of <i>Escherichia coli</i>
  • <i>Escherichia coli</i>の酵素活性に及ぼすビタミンKの影響

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Abstract

This investigation was undertaken to study the effects of four compounds, K3, K5, K3-Na-bisulfite and 2 Methyl-1, 4-naphthohydroquinone diacetate, on the enzymatic activities of the intact cells of bacteria.<br> (1) Succinic-, formic-, ethanol- and lactic-dehydrogenation was remarkably inhibtied by the prerrence of 14μg./ml. of K3, K5, and 24μg./ml. of K3-Na-bisulfite.<br> (2) Oxidative deamination of L-glutamic acid, L-alanine and tryptophan was inhibited by 30μg./ml. of K3, K5, and 50μg./ml. of K3-Na-bisulfite.<br> (3) 2 Methyl-1, 4-naphthohydroquinone diacetate had little effect on the dehydrogenation and the deamination at any degree of concentration tested.<br> (4) On catalase- and hydrogenase-activity, reduction of nitrate to nitrite, no marked inhibitory action of the four compounds was recorded even at a relatively higher degree of concentration as 100μg./ml.<br> (5) Decarboxylation of L-arginine and L-lysine was slightly accelerated even when the concentration of vitamin K compounds was as great as 150μg./ml.

Journal

  • NIPPON SUISAN GAKKAISHI

    NIPPON SUISAN GAKKAISHI 21 (10), 1076-1081, 1956

    The Japanese Society of Fisheries Science

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