子牛の発作性血色素尿(血)症の溶血機序に関する実験的研究

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  • The experimental study on the mechanism of hemolysis on paroxysmal hemoglobinemia and hemoglobinuria in calves due to excessive water intake.
  • 子牛の発作性血色素尿(血)症の溶血機序に関する実験的研究〔英文〕
  • コウシ ノ ホッサセイ ケッシキソ ニョウ チ ショウ ノ ヨウケツ キジョ

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When a calf became Paroxysmal Hemoglobinemia (-uria) by voluntary exces-sive water intake in extremely short period of time, the increment of plasma Fe conc.which normally indicates the degree of hemolysis, and the drop of plasma osmotic pressurein jugular vein were found not simultaneous. But, when dogs, a sheep and a calf wereintubated with water as much as 5% of respective body weight to their intestine, all animalsbecame hemoglobinernia, and in their mesenteric veins the reduction of plasma osmoticpressure and plasma Na and Cl conc. occurred nearly at the same time with the incrementof plasma Fe conc. The degree of the hemolysis and the drop of plasma osmotic pressurein mesenteric vein indicated similar trend to the results of in vitro exp. in which water ofvarious quantity was added to the whole blood. When a dog was intubated with normalsaline as much as 5% of its body weight to the intestine, the blood showed neither hemolysisnor decrement of plasma osmotic pressure in mesenteric, portal and jugular veins. Fromthese results, it was concluded that the hemolysis on Paroxysmal Ilemoglobinemia (-uria)could be caused by temporary extreme drop of plasma osmotic pressure in capillary veinswhere water was absorbed.

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