Mechanism for ApoE/HDL Generation and Cholesterol Homeostasis in the Brain

DOI Web Site Web Site 20 References
  • Ito Jinichi
    Department of Biochemistry, Nagoya City University Medical School

Bibliographic Information

Other Title
  • アストロサイトによるapoE/HDL 新生機構と脳のコレステロールホメオスタシス
  • アストロサイト ニ ヨル apoE HDL シンセイ キコウ ト ノウ ノ コレステロール ホメオスタシス

Search this article

Abstract

Neural cells such as neurons and glias in the central nervous system (CNS) appear in a multi-process with a large cell surface. Accordingly the CNS is a cholesterol-rich organ that accounts for approximately 25% of total body cholesterol in humans. As circulating plasma lipoproteins is segregated by the blood-brain barrier (BBB) from the CNS of vertebrates, a unique system for intercellular cholesterol transport functions in the brain. This review article describes the contribution of apoE/HDL generation by astrocytes to cholesterol homeostasis in the brain.

Journal

  • MEMBRANE

    MEMBRANE 32 (5), 259-265, 2007

    THE MEMBRANE SOCIETY OF JAPAN

References(20)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top