バベシア感染マウス新生仔におけるBabesia rodhaini感染に対する抵抗性

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  • Immunity in neonates of mice chronically infected with Babesia rodhaini.
  • バベシア感染マウス新生仔におけるBabesia rodhaini感染に対する抵抗性〔英文〕
  • バベシア カンセン マウス シンセイシ ニ オケル Babesia rodha

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The resistance of newborn mice to infection with Babesia rodhaini was studied. No parasites were detected in the neonates or fetuses of both acutely infected and chronically infected mothers. However, the neonates born of chronically infected mice and nursed by normal uninfected mothers or by chronically infected mice were significantly more resistant to the infection than those from normal uninfected mice. In experimentally infected adult mice, the activities of macrophage migration inhibitory factor (MIF) in the supernate of concomitant cultivation of spleen cells with the lysate antigen of Babesia increased up to 6 weeks after infection. The degree of peritoneal macrophage phagocytosis in infants from chronically infected mothers was significantly greater than that of normal mice. The macrophage phagocytosis of parasitized erythrocytes was enhanced remarkably when the erythrocytes were exposed to immune serum just before addition to the macrophages.

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