ネコ白血病ウィルス感染ネコにおけるインターロイキン2産性の低下

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タイトル別名
  • The decline in the production of Interleukin 2 in cats spontaneously infected with Feline Leukemia Virus.
  • ネコ白血病ウイルス感染ネコにおけるインターロイキン2産性の低下〔英文〕
  • ネコ ハッケツビョウ ウイルス カンセン ネコ ニ オケル インターロイキン

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Twelve cats, confirmed to be positive for group specific antigens of feline leukemia virus (FeLV) in peripheral blood lymphocytes (PBL) by an indirect immunofluorescent antibody test, were studied for interleukin 2 (IL-2) production. The production of IL-2, determined by the cell proliferation of an IL-2 dependent murine T cell line (CTLL-2), was remarkably lower in PBL from FeLV-infected cats, as compared to those from healthy controls. In particular, FeLV-infected cats with leukemia or with the thymic type of lymphosarcoma had substantially poor IL-2 production. These results suggest that the proliferative response of PBL from persistently FeLV-infected cats to Con A is reduced, associating with the lowered ability of IL-2 production at least in part.

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