Effect of phenobarbital on the absorption of copper by rat small intestine.

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  • 銅の腸管吸収におよぼすフェノバルビタールの影響
  • 銅の腸管吸収におよぼすフェノバルビタールの影響〔英文〕
  • ドウ ノ チョウカン キュウシュウ ニ オヨボス フェノバルビタール ノ エイ

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The effect of Phenobarbital (20, 40 and 80 mg/kg/day intraperitoneally for 5 days) on the absorption of copper from the rat small intestine was studied using an in situ recirculation technique. In untreated animals 45.7% of the initial amount of copper was absorbed after a 90-min recirculation. The pretreatment with phenobarbital resulted in a significant increase in the absorption of copper and at the end of 90 min of recirculation 56.7%, 62.7% and 70.0% of the initial amount were absorbed in the animals treated with phenobarbital at the dosages of 20, 40 and 80 mg/kg, respectively. To determine the absorption of copper from different sites of the small intestine, the intestine was divided into three segments of duodenum, jejunum and ileum. The copper absorption varied markedly in different segments and was the largest in duodenum followed in order of jejunum and ileum. Phenobarbital treatment resulted in a marked increase in the copper content in duodenum and jejunum as well as liver and kidney. Together with previous informations, the present data suggest that the phenobarbital-mediated increase in the copper absorption is related to increased synthesis of a carrier protein which may be involved in copper transport.

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