Lipid Emulsions Used as Models for Lipoproteins

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  • リポタンパクモデルとしての脂質エマルション表面膜の 性質と細胞との相互作用（動脈硬化の発生）
  • リポタンパク モデル ト シテ ノ シシツ エマルション ヒョウメン マク ノ セイシツ ト サイボウ ト ノ ソウゴ サヨウ ドウミャク コウカ ノ ハッセイ

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Abstract

Plasma lipoproteins play important roles for lipid homeostasis. Lipoproteins contain triglycerides and cholesteryl　ester in the core. The lipoprotein surface is formed by phospholipids and cholesterol, and various apolipoproteins　are bound to the surface of lipoprotein particles. Lipid emulsion particles have been used as models for plasma　lipoproteins. The lipid emulsions are prepared by the method using a high pressure emulsifier. Compared with plasma　lipoproteins, it is easy to alter the lipid composition of emulsion particles and apolipoproteins bound to emulsion　surface. Various lipids and proteins affect the lipoprotein metabolism, and are associated with hyperlipidemia and　atherosclerosis. However, the roles of many components of lipoprotein particles are still uncertain. Therefore, lipid　emulsions are useful for examining the mechanism of hyperlipidemia and atherosclerosis.

Journal

  • MEMBRANE

    MEMBRANE 32 (1), 11-17, 2007

    THE MEMBRANE SOCIETY OF JAPAN

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