Activation Mechanism of Receptors on the Biomembrane

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Other Title
  • 生体膜に存在する受容体活性化機構の解明
  • 生体膜に存在する受容体活性化機構の解明--ペプチド化学によるアプローチ
  • セイタイ マク ニ ソンザイ スル ジュヨウタイ カッセイカ キコウ ノ カイメイ ペプチド カガク ニ ヨル アプローチ
  • Approach from Peptide Chemistry
  • ぺプチド化学によるアプローチ

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Abstract

The biological importance of membrane protein is emphasized in statistical analyses of the genomes that indicateabout 30% of all open reading frames encode membrane proteins. For the purpose of performing structural biologyon membrane proteins, we have been developing a methodology for chemical synthesis of membrane proteins. Now,accumulated knowledge and experience has enabled us to work on the structure and function of transmembrane-jux-tamembrane region of membrane protein with solid state NMR and other spectroscopic techniques. Since littleattention has been paid to this portion of protein as such, obtaining the structural information thatprovides a clue tofully understand how membrane protein, especially, receptor on the membrane, passesthe structural change at theoutside to the inside. In this review, we introduce our approach from peptide chemistry to work on structural biolo-gy of membrane protein.

Journal

  • MEMBRANE

    MEMBRANE 34 (3), 110-116, 2009

    THE MEMBRANE SOCIETY OF JAPAN

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