マウス肝炎ウイルス感染ICRヌードマウスの全身性血管炎および糸球体腎炎
書誌事項
- タイトル別名
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- Systemic proliferative vasculitis and glomerulonephritis in ICR-nude mice infected with mouse hepatitis virus.
- マウス肝炎ウイルス感染ICRヌードマウスの全身性血管炎および糸球体腎炎〔英文〕
- マウス カンエン ウイルス カンセン ICR ヌードマウス ノ ゼン シンセイ
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ICR-nude mice inoculated intraperitoneally with MHV-NuU, showed progressive proteinuria and had virus in the kidney at 2 to 5 weeks postinoculation. In the renal glomeruli, mesangial and endothelial cells were enlarged and proliferated with infiltration of neutrophils, mononuclear cells and a few multinucleated giant cells. Proliferative endovasculitis was seen also in the brain, lung, liver, pancreas, omentum and mesentery. Immunofluorescence revealed MHV antigen within endothelial cells of the small veins, and multinucleated giant cells and glomerular mesangial cells. Segmental or diffuse deposition of immunogloblin as well as C3 were present in glomerular mesangial areas in association with MHV-antigen. By electron microscopy were seen degeneration of podocytes and hypertrophy of endothelial cells with subendothelial or paramesangial deposits. Virions were seen within vascular endothelial cells, macrophages and giant cells in and around the small vein but not within those in the glomeruli.
収録刊行物
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- 日本獸醫學雜誌(The Japanese Journal of Veterinary Science)
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日本獸醫學雜誌(The Japanese Journal of Veterinary Science) 48 (6), 1173-1182, 1986
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206421733248
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- NII論文ID
- 110003917474
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- NII書誌ID
- AN00191788
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- COI
- 1:STN:280:DyaL2s7kt1CisQ%3D%3D
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- ISSN
- 18811442
- 00215295
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- NDL書誌ID
- 3122598
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- PubMed
- 3820918
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可