Developmental susceptibilities of rabbits to various biological activities of bacterial endotoxin.
Bibliographic Information
- Other Title
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- 家兎の細菌内毒素に対する各種反応性の発育に伴う変化について
- 家兎の細菌内毒素に対する各種反応性の発育に伴う変化について〔英文〕
- カト ノ サイキンナイ ドクソ ニ タイスル カクシュ ハンノウセイ ノ ハツ
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Abstract
The developmental plaarmacology of endotoxin (Escherichia coli UKT-b) inthe rabbit was studied. When newborn rabbits were kept at a high ambient temperatureat which its basal metabolism was considered minimal, a small but definite febrile responsewas observed to endotoxin administered intravenously (0.5 pg/kg), subcutaneously (l pg/kg)or intracisternally (0.1 ng/kg). At room temperature (25C), such a significant febrileresponse was not observed. The febrile response increased in magnitude with the advancein age. Susceptibilities to the lethal effect of intravenous or intracisternal endotoxin werehigh in rabbits from the lst to 3rd day of life. They decreased over a period from the 7thto 21st day of life. Thereafter, tltey increased with the advance in age. Neither skinreaction nor shock by endotoxin was observed in rabbits under 21 days of age. Theseresults suggested that the receptor-effector mechanisms to endotoxin might be developedfairly in the CNS, but very poorly in the peripheral organs of rabbits in the early postnatal age.
Journal
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- The Japanese Journal of Veterinary Science
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The Japanese Journal of Veterinary Science 42 (6), 651-657, 1980
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390001206422220032
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- NII Article ID
- 110003977780
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- NII Book ID
- AN00191788
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- COI
- 1:STN:280:DyaL3M7psFehsg%3D%3D
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- ISSN
- 18811442
- 00215295
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- NDL BIB ID
- 2296437
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- PubMed
- 7014963
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed