銅による溶血とSuperoxide dismutaseとの関連性について

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タイトル別名
  • Hemolysis of bovine erythrocytes induced by copper and its relationship to superoxide dismutase activity.
  • 銅による溶血とSuperoxide dismutaseとの関連性について〔英文〕
  • ドウ ニ ヨル ヨウケツ ト Superoxide dismutase ト ノ

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Superoxide dismutase (SOD) activity and the percentage of hemolysis were measured with bovine erythrocytes incubated for 24 hrs at 37°C in 0.1 and 0.5mM copper sulfate solutions. The SOD activity decreased rapidly, as only 50% and 15% of the initial erythrocyte content (2.8×103units/g Hb) were found to be intact after 12 hrs incubation in 0.1 and 0.5mM copper sulfate solutions, respectively. Prior to the development of hemolysis and during the hemolytic phase, we detected a decrease in SOD activity. The percentage of hemolysis reached 30% and 80% after incubation for 24 hrs with 0.1 and 0.5mM copper sulfate solutions, respectively.

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