Formation of a Biocompatible Film <i>in vivo</i> -from Peritoneal Adhesion to Drug Delivery System-
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- Ito Taichi
- Center for Disease Biology and Integrative Medicine Faculty of Medicine, The University of Tokyo Department of Chemical System Engineering, The University of Tokyo
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- Suzuki Yukimitsu
- Department of Chemical System Engineering, The University of Tokyo
Bibliographic Information
- Other Title
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- 体内でのフィルム形成－腹膜癒着防止膜と薬物送達膜－
- タイナイ デ ノ フィルム ケイセイ フクマク ユチャク ボウシ マク ト ヤクブツ ソウタツ マク
- Formation of a Biocompatible Film in vivo -from Peritoneal Adhesion to Drug Delivery System-
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Abstract
Postoperative peritoneal adhesions cause pelvic pain, infertility, and potentially lethal bowel obstruction. We have designed and synthesized injectable hydrogels that are formed by mixing hydrazide-modified hyaluronic acid (HA) with aldehyde-modified versions of cellulose derivatives such as carboxymethylcellulose (CMC), hydroxypropylmethyl cellulose (HPMC), and methyl cellulose (MC). Hydrogels degraded in the presence of hyaluronidase in vitro, with HA-MC and HA-HPMC degrading more slowly than HAX and HA-CMC. All the cellulose-derived gels showed efficacy in reducing the area of adhesion formation in a rabbit sidewall defect-bowel abrasion model. In addition, we have designed and synthesized an injectable hydrogel composed of cross-linkable modified hyaluronic acids conjugated to dexamethasone, and investigated its anti-inflammatory function. The hydrogel degraded in media over 5 days, releasing dexamethasone slowly over that time preventing TNF-α production from lipopolysaccharide-stimulated primary mousice macrophages in vitro. Further research is on-going. We are designing cisplatin releasing system based on this in-situ crosslinkable hydrogel system for treating peritoneal dissemination.
Journal
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- MEMBRANE
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MEMBRANE 36 (2), 63-70, 2011
THE MEMBRANE SOCIETY OF JAPAN
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Keywords
Details 詳細情報について
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- CRID
- 1390001206422676864
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- NII Article ID
- 10029601681
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- NII Book ID
- AN0023215X
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- COI
- 1:CAS:528:DC%2BC3MXmtlamtr0%3D
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- ISSN
- 18846440
- 03851036
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- NDL BIB ID
- 11057543
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed
