書誌事項
- タイトル別名
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- Recent Advances in Understanding the Physiological Roles of ERM Proteins
- ERM タンパクシツ ノ アラタ ナ ヤクワリ ト セイリガクテキ イギ
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抄録
ERM (ezrin, radixin, and moesin) proteins were identified in 1980s. In the past three decades, many functions of these proteins in the re-organization of actin cytoskeleton, cell migration and cell-cell attachment, membrane-fusion, and the membrane targeting of the transporters and channels, were revealed. However, their physiological roles are not still fully elucidated. The generation of genetically modified animals yields the finding of new aspects of their physiological roles in vivo. In this review, we will discuss the recent advances in the finding of the new physiological roles of ERM proteins in several tissues, and the involvement of these proteins in the progression or the onset of the intractable diseases, and the possibility for the drug target.
収録刊行物
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- 膜
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膜 38 (4), 186-192, 2013
日本膜学会
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詳細情報 詳細情報について
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- CRID
- 1390001206422921728
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- NII論文ID
- 10031190690
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- NII書誌ID
- AN0023215X
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- COI
- 1:CAS:528:DC%2BC3sXhsFersLrE
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- ISSN
- 18846440
- 03851036
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- NDL書誌ID
- 024813001
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- KAKEN
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- 抄録ライセンスフラグ
- 使用不可