Recent Advances in Understanding the Physiological Roles of ERM Proteins

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  • Hatano Ryo
    College of Pharmaceutical Sciences, Ritsumeikan University
  • Asano Shinji
    College of Pharmaceutical Sciences, Ritsumeikan University

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  • ERMタンパク質の新たな役割と生理学的意義
  • ERM タンパクシツ ノ アラタ ナ ヤクワリ ト セイリガクテキ イギ

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Abstract

ERM (ezrin, radixin, and moesin) proteins were identified in 1980s. In the past three decades, many functions of these proteins in the re-organization of actin cytoskeleton, cell migration and cell-cell attachment, membrane-fusion, and the membrane targeting of the transporters and channels, were revealed. However, their physiological roles are not still fully elucidated. The generation of genetically modified animals yields the finding of new aspects of their physiological roles in vivo. In this review, we will discuss the recent advances in the finding of the new physiological roles of ERM proteins in several tissues, and the involvement of these proteins in the progression or the onset of the intractable diseases, and the possibility for the drug target.

Journal

  • MEMBRANE

    MEMBRANE 38 (4), 186-192, 2013

    THE MEMBRANE SOCIETY OF JAPAN

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