Immunologic properties of variants dissociated from serotype 1 Haemophilus paragallinarum strains.

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  • Haemophilus paragallinarum 血清型1 (血清型HA-1) 菌株から作出した変異株の免疫学的性状
  • Haemophilus paragallinarum血清型1(血清型HA-1)菌株から作出した変異株の免疫学的性状〔英文〕
  • Haemophilus paragallinarumケツセイガタ 1 ケツセイ

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Abstract

Immunogenic properties of seven variants having different morphologic, serologic, and pathogenic properties, which were dissociated from serotype 1 (serotype HA-1) Haemophilus paragallinarum, were investigated in chicks. Protective immunity was induced by injection with any of the four variants possessed both heat-labile, trypsin-sensitive, hyaluronidase-resistant, serotype 1-specific L1 and HA-L1 antigens. The immuned chicks had antibodies specific to serotype 1, agglutinin against L1 antigen and hemagglutination-inhibition (HI) antibodies against HA-L1 antigen. In contrast, the other three variants lacking both the antigens did not induce protection. Hyaluronidase-treatment of the hi variant consisting of highly encapsulated organisms abolished its virulence without affecting the protective activity and antibody-producing ability against antigens L1 and HA-L1. These results support our hypothesis that the antigens L1 and HA-L1, are responsible for immunogenicity.

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