Species specificity of Haemophilus pleuropneumoniae hemolysin demonstrated in the cytocidal and anti-phagocytic effects.

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  • Haemophilus pleuropneumoniaeヘモリジンの細胞障害作用における動物種特異性
  • Haemophilus pleuropneumoniaeヘモリジンの細胞障害作用における動物種特異性〔英文〕(短報)
  • Haemophilus pleuropneumoniae ヘモリジン ノ サイ

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Abstract

Hemolysin was prepared from the culture supernatant of Haemophilus pleuropneumoniae, and its cytocidal and anti-phagocytic effects were investigated with pulmonary macrophages (PMP) obtained from the pig, mouse, guinea pig, or cotton rat. The hemolysin demonstrated both cytocidal and anti-phagocytic activities with the cotton rat, guinea pig, and pig PMP cells, but not with the mouse PMP cells. The species specificity in the cytocidal and anti-phagocytic effects with the PMP cells may be important in analyzing for the pathogenesis of the organisms to various animal species.

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