書誌事項
- タイトル別名
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- Observation of Calcium Activities in Newron-Glia Co-cultured System: Searching for underling mechanism.
- コウエンロク シンケイ グリア サイボウケイ ニ オケル カルシウムハ ト カルシウム シンドウ ソノ ソクテイ ト ハッセイ キコウ
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抄録
Cultured neural network is a useful tool for the understanding of fundamental functions and structure of nervous system. In this biological neural network, nerve cells mutually communicate by electrical or chemical interactions, and exhibit collective dynamics of activities such as synchronous bursting or calcium wave propagation. Photostimulation by using caged-glutamate were performed to elucidate the mechanism of Ca wave propagations through the measurement of the speed of Ca wave, rising time of Ca increase, and range of propagation, etc. To analyze the activity and dynamical connectivity of the cultured network, we quantified spontaneous collective dynamics of the network by lowering magnesium concentration in extracellular solution. From the visualization of network structure, cell type discrimination by MAP2 monochronal antibody, and measurement of dynamical activity by [Ca2+] sensitive dye, we quantitatively elucidated that collectivity of the network activities were increased due to the development of long-range interaction between neurons.
収録刊行物
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- 膜
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膜 26 (6), 251-258, 2001
日本膜学会
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詳細情報 詳細情報について
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- CRID
- 1390001206423099264
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- NII論文ID
- 10008010876
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- NII書誌ID
- AN0023215X
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- ISSN
- 18846440
- 03851036
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- NDL書誌ID
- 5992376
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可