Application of Surface–modified Liposomes with Succinic Acid for Drug Delivery System Targeting Bone Marrow

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  • Sou Keitaro
    Waseda Bioscience Research Institute in Singapore （WABIOS） Organization for University Research Initiatives, Waseda University

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Other Title
  • コハク酸で表面修飾したリポソームの骨髄標的化DDSへの応用
  • コハクサン デ ヒョウメン シュウショク シタ リポソーム ノ コツズイ ヒョウテキカ DDS エ ノ オウヨウ

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Abstract

The capsular structure of liposomes is attractive for encapsulation of pharmaceuticals to develop nanoparticle-based drug delivery systems. Here unique liposomes which are modified with succinic acid on their surface arereviewed at a point of view of drug delivery carriers. The negatively charged carboxyl group of the succinic acid onthe surface of the liposomes contributes to facilitate the formation of the unilamellar liposomes which have superiorability to efficiently encapsulate the pharmaceuticals. Interestingly, we found that the liposomes modified with suc-cinic acid are highly distributed in the bone marrow through the intravenous injection. These characteristics of thesurface–modified liposomes with succinic acid would be applicable for the drug delivery system targeting bone mar-row.

Journal

  • MEMBRANE

    MEMBRANE 39 (5), 290-295, 2014

    THE MEMBRANE SOCIETY OF JAPAN

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