酸化物基板表面上の支持平面脂質二重膜内でのドメイン形成と分子拡散挙動のその場観察

  • 手老 龍吾
    豊橋技術科学大学 エレクトロニクス先端融合研究所

書誌事項

タイトル別名
  • Domain Formation and Molecular Diffusion in Supported Lipid Bilayers on Oxide Surfaces
  • サンカブツ キバン ヒョウメン ジョウ ノ シジ ヘイメン シシツ ニジュウ マク ナイ デ ノ ドメイン ケイセイ ト ブンシ カクサン キョドウ ノ ソノバ カンサツ

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抄録

Dynamics in lipid bilayers such as two dimensional domain formation and lateral molecular transportation are crucial factors in cell membrane reactions. In this review several recent studies about the domain formations and molecular diffusion using supported planar lipid bilayers (SLBs) are introduced. SLBs exist at the interface between solid substrates and aqueous solutions, 1 ∼ 2 nm away from the substrate. The fluidity of the membrane remains while the membrane is still affected by the structure and the physical properties of the substrate surface. Two dimensional domain structures on the lateral order of several micrometers in SLB are affected by the atomic scale structures of the substrate. At the latter half of this review, the method of single molecule tracking free from the restriction of substrate materials is described. Lipid diffusions in SLBs on opaque silicon wafer and high refractive TiO2 substrate were observed in situ and the diffusion coefficients were successfully obtained.

収録刊行物

  • 膜 36 (1), 16-23, 2011

    日本膜学会

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