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- 岡本 貴行
- 三重大学大学院 医学系研究科 分子病態学
書誌事項
- タイトル別名
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- Contribution of Gap Junctions to the Function of the Vascular Endothelium
- ギャップジャンクション ト ケッカン ナイヒ キノウ
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抄録
Gap junctions (GJs) are comprised of members of the connexin (Cx) family and endothelial GJs play an important role in vascular function, stability, and homeostasis. Endothelial cells (ECs) communicate to adjacent ECs, vascular smooth muscle cells, leukocytes and platelets via GJ, thereby Cx–mediated interactions with each type of cells have shown different effects over a wide range of vascular functions. Endothelium regulates vascular inflammation, blood coagulation, vasodilation/ vasoconstriction, angiogenesis, and vascular stiffness. Endothelial dysfunction is related to cardiovascular diseases such as atherosclerosis. The alteration of Cxs expression in vascular component cells contributes to the development of endothelial dysfunction and cardiovascular diseases. We have summarized here the role of GJs in the function of the vascular endothelium.
収録刊行物
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- 膜
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膜 41 (2), 61-67, 2016
日本膜学会
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詳細情報 詳細情報について
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- CRID
- 1390001206423334272
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- NII論文ID
- 130005249085
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- NII書誌ID
- AN0023215X
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- ISSN
- 18846440
- 03851036
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- NDL書誌ID
- 027208609
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可