雄マウス精細胞に対する N-nitroso-ethylenethiourea の作用について

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  • Effect of N-nitroso-ethylenethiourea on germinal cells in male mice.
  • 雄マウス精細胞に対するN-nitroso-ethylenethioureaの作用について〔英文〕
  • ユウ マウス セイサイボウ ニ タイスル N nitroso ethylene

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The effect of N-nitroso-ethylenethiourea (N-nitroso-ETU) on germinal cells of male mice was investigated by a time-course study of histology including a semi-quantitative analysis on the distribution of germinal cells. After a single peroral dose of 200 mg/kg of N-nitroso-ETU, the testes were examined on each of days 4, 7, 10, 14, 21, 28, 35, 42, and 49. Testicular weights showed a progressive decrease until day 21 followed by a gradual recovery afterwards. In histological analysis the minimal incidence of each germinal cell, i. e., spermatogonium, spermatocyte, spermatid, and spermatozoon, was observed on days 4, 14, 21 and 28 after the treatment, respectively. Temporal depletion of sperm from ductal lumen of the epididymides was observed on day 35. These results indicated that N-nitroso-ETU selectively affected spermatogonia, producing consequent temporal azoospermia or oligozoospermia.

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