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- 岩田 基数
- Formulation Research & Development Laboratories Technology Reseach & Development, Dainippon Sumitomo Pharma Co.,Ltd.
書誌事項
- タイトル別名
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- Design of Fast Disintegrating Tablets and Orally Disintegrating Tablet by Reduction of Hydrophobic Lubricant
- ソスイセイ カッタクザイ ノ ゲンリョウ ニ ヨル ソクホウカイジョウ オヨビ コウコウ ナイ ホウカイジョウ ノ セッケイ
この論文をさがす
抄録
Orally disintegrating tablet (OD tablet) disintegrates rapidly by penetration of saliva and shear stress and/or pressure in mouth. Therefore, it is easy to swallow this tablet without chewing or taking water together. Recently, OD tablet has become more popular and preferred dosage form from the view point of not only good swallowability to elder patients but also compliance improvement. This dosage form is not novel and has been manufactured in part of the fast disintegrating tablet. To design and formulate OD tablet, it is necessary to take a conflicting balance in performance between sufficient hardness of the tablet and fast disintegrating property in mouth. The content of hydrophobic lubricant in the tablet is one of the important factors which determine such performance of the tablet. Two marketed products are introduced in this report: PYLONICR Tablet (fast disintegrating tablet) and EBASTELR OD Tablet (OD tablet) both of which were designed and formulated based on a common idea to reduce amount of hydrophobic lubricant in a tablet.
収録刊行物
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- 膜
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膜 38 (1), 57-61, 2013
日本膜学会
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詳細情報 詳細情報について
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- CRID
- 1390001206423458432
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- NII論文ID
- 10031147453
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- NII書誌ID
- AN0023215X
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- COI
- 1:CAS:528:DC%2BC3sXmslCksrk%3D
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- ISSN
- 18846440
- 03851036
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- NDL書誌ID
- 024253638
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可