Relationship between anticapsular antibody and protective activity of a capsular antigen of Haemophilus paragallinarum.
Bibliographic Information
- Other Title
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- Haemophilus paragallinarum の莢膜抗体と莢膜抗原の感染防御能
- Haemophilus paragallirarumの抗莢膜抗体と莢膜抗原の感染防御能〔英文〕
- Haemophilus paragallirarum ノ コウ キョウマク コ
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Abstract
Relationship between anticapsular antibody and protective activity of a capsular antigen of Haemophilus paragallinarum serotype HA-1 strain 221 was investigated. A capsular antigen was extracted from encapsulated organisms of the hi variant by various procedures. Indirect hemagglutination (IHA) test was used for detecting anticapsular antibodies. The IHA antibodies against a formalin-saline-extracted and phenol-treated antigen prepared with hi variant (hi-FSEx-P antigen) were specifically found in hi-NT antisera prepared from nontreated (NT) antigens of hi variant, and IHA activity of the antibodies found in hi-NT antiserum was specifically inhibited by the hi-FSEx-P antigen. The capsular antigen was found to be heat-stable and hyaluronidase-resistant. Chicks injected intravenously with hi-FSEx-P antigen produced anticapsular antibodies, and protection against the challenge exposure with 221-hi organisms was not observed in these chicks despite the presence of IHA antibodies. The results showed that protective activity of H. paragallinarum dose not reside in a capsular antigen, and that anticapsular antibody formation significantly depends on a route of injection and on ages of chicks.
Journal
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- The Japanese Journal of Veterinary Science
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The Japanese Journal of Veterinary Science 46 (4), 475-486, 1984
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390001206423808128
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- NII Article ID
- 110003917259
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- NII Book ID
- AN00191788
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- COI
- 1:STN:280:DyaL2M%2FjsVGntw%3D%3D
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- ISSN
- 18811442
- 00215295
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- NDL BIB ID
- 2999385
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- PubMed
- 6492537
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed