Experimental Chemotherapy against Canine Mammary Cancer Xenograft in SCID Mice and Its Prediction of Clinical Effect.
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- YAMASHITA Atsuko
- Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology
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- MARUO Kohji
- Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology
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- SUZUKI Kaoru
- Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology
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- SHIROTA Kinji
- Research Institute of Bioscience, Azabu University
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- KOBAYASHI Kimio
- The Central Institute of Experimental Animals
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- HIOKI Kyoji
- The Central Institute of Experimental Animals
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抄録
The effectiveness of 6 antitumor agents has been evaluated for canine mammary gland tumor (CMG-6) serially transplanted into severe combined immunodeficiency (SCID) mice. CMG-6 diagnosed as a solid carcinoma was subcutaneously transplanted into SCID mice and six antitumor agents were intravenously given to the mice as a single injection. The effectiveness was evaluated by Treatment group/Control group percent (T/C %) and statistical significance determined by Mann-Whitney's U-test in tumor volume. The minimum effective doses (MEDs; mg/kg) of mice were as follows; cyclophosphamide (CPM) 65, doxorubicin (DXR) 6, cisplatin (CDDP) 5, vincristine (VCR) 1.6, vinblastine (VLB) more than 5.5, 5-fluorouracil (5-FU) 105. Clinical effects of the drugs were predicted based on area under the curve (AUC) of dogs given a clinical dose (AUCdog)/AUC of mice given a MED (AUCmouse) ratios from published references. The AUC ratios were as follows; CPM 2.24, DXR 0.19, CDDP 1.20, VCR 0.04, VLB <1.24 and 5-FU 1.15. Drugs indicating more than 1.0 in AUCdog/AUCmouse ratio were CPM, CDDP and 5-FU, and would be suggested as effective in the original patient with CMG-6. The combination chemotherapy using clinically equivalent doses in CDDP and CPM, which were the two highest values in AUCdog/AUCmouse ratio by single agent therapy, was performed and shown to have additional effects as compared to the responsiveness of each agent against CMG-6.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 63 (8), 831-836, 2001
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206424180736
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- NII論文ID
- 110003920702
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD3MXntVKrsLk%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 5888661
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- PubMed
- 11558535
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可