Antiinflammatory Effect of Japanese Horse Chestnut (Aesculus turbinata) Seeds

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  • SATO Itaru
    Laboratory of Veterinary Public Health, Faculty of Agriculture, Iwate University
  • KOFUJITA Hisayoshi
    Laboratory of Forest Product Chemistry, Faculty of Agriculture, Iwate University
  • SUZUKI Tadahiko
    Laboratory of Veterinary Pharmacology, Faculty of Agriculture, Iwate University
  • KOBAYASHI Haruo
    Laboratory of Veterinary Pharmacology, Faculty of Agriculture, Iwate University
  • TSUDA Shuji
    Laboratory of Veterinary Public Health, Faculty of Agriculture, Iwate University

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  • 栃(Aesculus turbinata)の実の抗炎症作用

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Abstract

The antiinflammatory effects of Japanese horse chestnut (Aesculus turbinata) seeds were examined in vivo and in vitro. The extract of this seed (HCSE) inhibited croton oil-induced swelling of the mouse concha. HCSE inhibited cyclooxygenase (COX) -1 and -2 activities, but had no effect on 15-lipoxygenase and phospholipase A2 activities. Inhibition of COX-2 occurred at a lower concentration of HCSE than for COX-1. Japanese horse chestnut seeds contain coumarins and saponins, but these chemicals did not inhibit COX activities. These results suggest that the antiinflammatory effect of Japanese horse chestnut seeds is caused, at least partly, by the inhibition of COX. The inhibitor of COX in this seed may be a chemical(s) other than coumarins and saponins.<br>

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