Immunohistochemical Study of Osteopontin in the Spinal Cords of Rats with Clip Compression Injury
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- MOON Changjong
- Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University
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- HEO Seungdam
- Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University
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- AHN Meejung
- Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University
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- KIM Heechul
- Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University
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- SHIN Myungseung
- Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University
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- SIM Ki Bum
- Department of Neurosurgery, College of Medicine, Cheju National University
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- KIM Hyung Min
- Department of Pharmacology, College of Oriental Medicine, Kyung-Hee University
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- SHIN Taekyun
- Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University
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Abstract
Expression of osteopontin (OPN) was investigated in the spinal cords of rats with clip compression injury. Western blot analysis demonstrated that OPN protein increased significantly in the spinal cord during the early stages after injury. The increased expression of OPN was partially paralleled by that of proliferating cell nuclear antigen (PCNA). Immunohistochemical staining showed that OPN was expressed in proliferating activated microglia/macrophages in core lesions and in some astrocytes at the periphery of lesions. These results indicate that expression of OPN protein increases mainly in activated microglia/macrophages after spinal cord injury, suggesting that OPN is related to cell proliferation during the early stages after injury, probably leading to tissue remodeling.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 66 (10), 1307-1310, 2004
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Keywords
Details 詳細情報について
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- CRID
- 1390001206424363904
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- NII Article ID
- 110003886363
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- NII Book ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 7130101
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- PubMed
- 15528873
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed