Anti-obesity effects of selective agonists to the β3-adrenergic receptor in dogs(1)The presence of canine β3-adrenergic receptor and in vivo lipomobilization by its agonists
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- SASAKI Noriyasu
- Laboratory of Biochemistry, Department of Biomedical Sciences, School of Veterinary Medicine, Hokkaido University
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- UCHIDA Eiji
- Department of Internal Medicine II, Rakuno Gakuen University
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- NIIYAMA Masayoshi
- Department of Internal Medicine II, Rakuno Gakuen University
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- YOSHIDA Toshihide
- Department of Internal Medicine, Kyoto Prefectural University of Medicine
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- SAITO Masayuki
- Laboratory of Biochemistry, Department of Biomedical Sciences, School of Veterinary Medicine, Hokkaido University
書誌事項
- タイトル別名
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- Anti-Obesity Effects of Selective Agonists to the .BETA.3-Adrenergic Receptor in Dogs. I. The Presence of Canine .BETA.3-Adrenergic Receptor and in vivo Lipomobilization by Its Agonists.
- Anti-obesity effects of selective agoni
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説明
It is known that in rodents and humans the β3-adrenergic receptor (β3-AR) is present primarily in adipocytes and plays a significant role in the adrenergic stimulation of lipolysis. We examined the expression of β3-AR mRNA in the dog and the lipomobilizing effects of β3-AR-selective agonists in vivo. Reverse transcription polymerase chain reaction of RNA extracted from dog adipose tissue produced a cDNA fragment, the nucleotide sequence of which was highly homologous to the corresponding regions of human (86.4%) and mouse (79.5%) β3-AR cDNA. The β3-AR mRNA was present at high levels in subcutaneous and visceral adipose tissues, but undetectable in other organs. When a selective β3-AR agonist, CL316, 243, was infused intravenously into beagle dogs, the plasma level of free fatty acid increased in 30 min and persisted at higher levels for several hours. ICI D7114, another β3-AR agonist, also showed a similar lipomobilizing effect, but with lower potency. β3-AR agonist infusion also increased the plasma insulin level. These results suggested that functional β3-AR is present in adipose tissues of the dog and that it is effective for in vivo lipomobilization.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 60 (4), 459-463, 1998
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206424415616
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- NII論文ID
- 110003947906
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DyaK1cXjtFWjtrs%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 4459911
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- PubMed
- 9592718
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可