Role of Gap Junctional Intercellular Communication (GJIC) through p38 and ERK1/2 Pathway in the Differentiation of Rat Neuronal Stem Cells
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- YANG Se-Ran
- Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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- CHO Sung-Dae
- Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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- AHN Nam-Shik
- Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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- JUNG Ji-Won
- Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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- PARK Joon-Suk
- Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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- JO Eun-Hye
- Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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- HWANG Jae-Woong
- Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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- JUNG Ji-Youn
- Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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- KIM Tae-Yung
- Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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- YOON Byoung-Su
- Laboratory of Genetics, Department of Biology, College of Natural Science, Kyonggi University
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- LEE Bong-Hee
- Department of Anatomy and Neurobiology, College of Medicine, Institute of Medical Science, Cheju National University
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- KANG Kyung-Sun
- Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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- LEE Yong-Soon
- Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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Abstract
Gap junctional intercellular communications (GJIC) contributes to neural function in development and differentiation of CNS. In this study, we have investigated the expression of GJIC during the differentiation of neuronal stem cells and 12-Ø-tetradecanoylphorbol-13-acetate (TPA)-induced neuronal stem cell-derived cells from rat brain. During neuronal stem cell differentiation, expressions of Cx43 and 32 were increased for the duration of 72 hr, however the effect were decreased on the 7d. In the neuronal stem cell-derived cells, pretreatments with p38 MAP kinase inhibitor, SB203580, and MEK inhibitor, PD98059, could protect GJIC against TPA-induced inhibition of GJIC. Our data suggest that GJIC plays an important role during neuronal stem cell differentiation, and ERK1/2 and p38 MAP kinase signaling pathway may be closely related functionally to regulate gap junction in rat neuronal stem cell-derived cells.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 67 (3), 291-294, 2005
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390001206424679168
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- NII Article ID
- 110003963721
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- NII Book ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 7293201
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- PubMed
- 15805733
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed