Molecular Analysis of Defect Healing in Rat Diaphyseal Bone.
-
- CHIBA Shuichi
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
-
- OKADA Kosuke
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
-
- LEE Kaechoong
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
-
- SEGRE Gino V.
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
-
- NEER Robert M.
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
この論文をさがす
説明
Spatial expression of messenger ribonucleic acid (mRNA) for osteoblastic marker in drill hole defect healing of adult male rats was analyzed by in situ hybridization. The defect was filled with hematoma 3 days after surgery, expressing Type I collagen mRNA. Hematoma was replaced with fibrous tissue on day 7, and then with new trabecular bone on day 10, originated from the intra-medullary space, respectively. mRNA for Type I collagen, parathyroid hormone 1 receptor (PTH1R), and alkaline phosphatase (ALP) were expressed in the same cell population of fibrous tissue adjacent to newly-formed trabecular bone, and in osteoblasts lining the newly-formed trabecular bone. Hematopoietic marrow with osteoclasts subsequently invaded the region, also from the intra-medullary space, replacing all the new trabecular bone by day 21, except for a thin sub-periosteal layer. mRNA for Type I collagen, PTH1R and ALP was expressed on the periosteal surface of thin layer. Although cartilage formation was not histologically visible, mRNA for Type II collagen was weakly detected in the majority of osteoblasts lining the newly-formed trabecular bone.
収録刊行物
-
- The Journal of Veterinary Medical Science
-
The Journal of Veterinary Medical Science 63 (6), 603-608, 2001
公益社団法人 日本獣医学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206425265920
-
- NII論文ID
- 130000449591
- 110003920663
-
- NII書誌ID
- AA10796138
-
- COI
- 1:STN:280:DC%2BD38%2Fit1Khuw%3D%3D
-
- ISSN
- 13477439
- 09167250
-
- NDL書誌ID
- 5820328
-
- PubMed
- 11459005
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可