Peripheral Neuroblastoma in a Young Labrador Retriever.

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  • SUZUKI Mari
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
  • UCHIDA Kazuyuki
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
  • TANIGUCHI Kaoru
    Taniguchi Animal Clinic
  • YAMAGUCHI Ryoji
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University
  • TATEYAMA Susumu
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University

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  • 若齢ラブラドールレトリバーに発生した末梢神経芽細胞腫の1例

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A 2-year-old Labrador Retriever developed atrophy of the right temporal muscle, subsequently showed generalized seizure and died 2 months after the clinical onset. Postmortem examination revealed the tumor masses in the right mandibulopharyngeal area, nasopharynx and intracranial space. Histopathologically, these tumor masses were composed of small round neoplastic cells and neuropil-like stroma separated by fibrovascular septa. In the neoplastic masses, small neoplastic cells with round to oval hyperchromatic nuclei and scanty cytoplasm predominated, and angulated neoplastic cells with larger nuclei and moderate cytoplasm were scattered. Immunohistochemically, neoplastic cells were positive for neuron specific enorase, neurofilament protein, chromogranin A, synaptophysin and tyrosine hydroxylase. Based on these findings, this case was diagnosed as peripheral neuroblastoma, presumably originated from the sympathetic ganglion, maybe right craninal cervical ganglion.<br>

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